Kliqqi Social Bookmarking - Estrogen stimulates cGMP synthesis of cardiac myocytes via the eNOS/sGC pathway, serving as a predominant cGMP https://pligg.samweber.biz/story.php?title=estrogen-stimulates-cgmp-synthesis-of-cardiac-myocytes-via-the-enossgc-pathway-serving-as-a-predominant-cgmp Therefore, we tested whether male hearts were equipped with a PDE5-coupled cGMP regulatory system that is less estrogen dependent. Gender differences in Fildena responses and the mechanism involving eNOS-cGMP synthesis and PKG activation under cardiac stress. (B) PDE5 activity in Gq/oe female hearts subjected to sham operation (non-OVX), OVX, and OVX with E2 replacement (n = 5-8 per group). Wed, 18 Jul 2018 10:06:08 UTC en