Filagra, which is present in the commercial agent Fildena, used for the treatment of erectile dysfunction, specifically inhibits the breakdown of cellular cGMP by PDE5 ( 33 ) and thereby prolongs and enhances the effects of the NO/cGMP pathway. The end-of-treatment mean scores for Q3 (ability to achieve an erection), Q4 (ability to maintain an erection), and Q7 (satisfaction with treatment) of the
Therefore, we tested whether male hearts were equipped with a PDE5-coupled cGMP regulatory system that is less estrogen dependent. Gender differences in Fildena responses and the mechanism involving eNOS-cGMP synthesis and PKG activation under cardiac stress. (B) PDE5 activity in Gq/oe female hearts subjected to sham operation (non-OVX), OVX, and OVX with E2 replacement (n = 5-8 per group).
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