Among users of PDE5 inhibitors, 734 men (34%) had filled a single prescription, 804 men (37%) had 2 through 5 prescriptions, and 610 men (28%) had filled 6 or more prescriptions (eTable 1 in the Supplement ). In multivariable analysis, the risk of melanoma was significant for men who had filled a single prescription (OR, 1.32 95% CI, 1.10-1.59; 4% for cases vs 3% for controls) but not for men with
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